A agentindex
Comparison

AutoGen vs Letta

A like-for-like, spec-level comparison. Both entries are verified against their docs and repo.

AutoGen

Microsoft's framework for multi-agent conversations.

  • + Backed by Microsoft research
  • + Strong on conversational agent patterns
  • − API churned across major versions
  • − Heavier abstraction layer

Letta

Stateful agents with long-term memory (formerly MemGPT).

  • + First-class long-term memory and stateful agents
  • + Lets agents persist and self-edit context
  • − Narrower focus than general orchestration frameworks
  • − Memory model adds complexity
Spec AutoGen Letta
Role Agent framework Agent framework
Tags agent-framework, library, multi-agent agent-framework, library, multi-agent
License MIT Apache-2.0
Open source Yes Yes
Self-hostable Yes Yes
MCP support Yes Yes
Pricing free freemium
Starting price BYOK usage cost Self-host free
Models claude, gpt, gemini, byok claude, gpt, gemini, byok
Languages python, dotnet python
GitHub stars 59.3k 23.5k
Last activity 2026-04-15 2026-06-26